Concepts and Case Studies in Chemical Biology, 2nd Edition Front Cover

Concepts and Case Studies in Chemical Biology, 2nd Edition

  • Length: 464 pages
  • Edition: 2
  • Publisher:
  • Publication Date: 2014-10-06
  • ISBN-10: 3527336117
  • ISBN-13: 9783527336111
  • Sales Rank: #3759157 (See Top 100 Books)
Description

Retaining the proven didactic concept of the successful “Chemical Biology – Learning Through Case Studies”, this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world’s leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.

Table of Contents

Chapter 1 Real-Time and Continuous Sensors of Protein Kinase Activity Utilizing Chelation-Enhanced Fluorescence
Chapter 2 FLiK and FLiP: Direct Binding Assays for the Identification of Stabilizers of Inactive Kinase and Phosphatase Conformations
Chapter 3 Strategies for Designing Specific Protein Tyrosine Phosphatase Inhibitors and Their Intracellular Activation
Chapter 4 Design and Application of Chemical Probes for Protein Serine/Threonine Phosphatase Activation
Chapter 5 Autophagy: Assays and Small-Molecule Modulators
Chapter 6 Elucidation of Protein Function by Chemical Modification
Chapter 7 Inhibition of Oncogenic K-Ras Signaling by Targeting K-Ras-PDEδ Interaction
Chapter 8 Development of Acyl Protein Thioesterase 1 (APT1) Inhibitor Palmostatin B That Revert Unregulated H/N-Ras Signaling
Chapter 9 Functional Analysis of Host-Pathogen Posttranslational Modification Crosstalk of Rab Proteins
Chapter 10 Chemical Biology Approach to Suppression of Statin-Induced Muscle Toxicity
Chapter 11 A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo-Cross-Linking Beads
Chapter 12 Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology
Chapter 13 Rational Design of Activity-Based Retaining β-Exoglucosidase Probes
Chapter 14 Modulation of ClpP Protease Activity: from Antibiotics to Antivirulence
Chapter 15 Affinity-Based Isolation of Molecular Targets of Clinically Used Drugs
Chapter 16 Identification of the Targets of Natural-Product-Inspired Mitotic Inhibitors
Chapter 17 Finding a Needle in a Haystack. Identification of Tankyrase, a Novel Therapeutic Target of the Wnt Pathway Using Chemical Genetics
Chapter 18 The Identification of the Molecular Receptor of the Plant Hormone Abscisic Acid
Chapter 19 Chemical Biology in Plants: Finding New Connections between Pathways Using the Small Molecule Sortin1
Chapter 20 Selective Targeting of Protein Interactions Mediated by BET Bromodomains
Chapter 21 The Impact of Distant Polypharmacology in the Chemical Biology of PARPs
Chapter 22 Splicing Inhibitors: From Small Molecule to RNA Metabolism
Chapter 23 Photochemical Control of Gene Function in Zebrafish Embryos with Light-Activated Morpholinos
Chapter 24 Life Cell Imaging of mRNA Using PNA FIT Probes
Chapter 25 Targeting the Transcriptional Hub β-Catenin Using Stapled Peptides
Chapter 26 Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems
Chapter 27 Scaffold Diversity Synthesis with Branching Cascades Strategy

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