Essentials of Pharmacokinetics and Pharmacodynamics, 2nd Edition

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Table of Contents

CHAPTER 1: Opening Comments

SECTION I: Basic Considerations
CHAPTER 2: Input–Exposure Relationships
CHAPTER 3: Exposure–Response Relationships

SECTION II: Exposure and Response After a Single Dose
CHAPTER 4: Membranes: A Determining Factor
CHAPTER 5: Quantifying Events Following an Intravenous Bolus
CHAPTER 6: Physiologic and Physicochemical Determinants of Distribution and Elimination
CHAPTER 7: Quantifying Events Following an Extravascular Dose
CHAPTER 8: Physiologic and Physicochemical Determinants of Drug Absorption
CHAPTER 9: Response Following a Single Dose

SECTION III: Therapeutic Regimens
CHAPTER 10: Therapeutic Window
CHAPTER 11: Constant-Rate Regimens
CHAPTER 12: Multiple-Dose Regimens

SECTION IV: Individualization
CHAPTER 13: Variability
CHAPTER 14: Initiating and Managing Therapy

APPENDIX A: Definitions of Symbols
APPENDIX B: Medical Words and Terms
APPENDIX C: Ionization and the pH Partition Hypothesis
APPENDIX D: Assessment of AUC
APPENDIX E: Amount of Drug in the Body on Accumulation to Plateau
APPENDIX F: Answers to Study Problems