Genomic Medicine: Principles and Practice, 2nd Edition

The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.

Table of Contents

Part I: Principles of Genomic Medicine
Chapter 1. Genes, Genetics, and Human Genomics
Chapter 2. The human genome-structure and organization
Chapter 3. Human proteomics
Chapter 4. Epigenetics, epigenomics, and human disease
Chapter 5. Genes, genome, and developmental malformations
Chapter 6. Bioinformatics, systems biology, and systems medicine
Chapter 7. Pharmacogenomics—critical component of genomic medicine
Chapter 8. New drug development, drug response, and precision medicines
Chapter 9. Mitochondrial genetics and genomics in clinical medicine
Chapter 10. Genomics technology in clinical diagnostics
Chapter 11. Microbial genomics: targeted antimicrobial therapy and genome vaccines
Chapter 12. Nutritional genomics
Chapter 13. Genomics in public and population health
Chapter 14. Genetic testing and genomic screening
Chapter 15. Biobanking for genomics-based translational medicine
Chapter 16. Genetics and genomics education: the path from helix to health
Chapter 17. Ethical, legal, and social issues in clinical genomics
Chapter 18. The regulation of human genomics research

Part II: Genomics in Clinical Practice
Chapter 19. Genetic and genomic approaches to clinical medicine
Chapter 20. Genetic and genomic taxonomy of human disease
Chapter 21. Genomics of complex cardiovascular disease
Chapter 22. Genomics of type 2 diabetes mellitus and obesity
Chapter 23. Genetics and genomics of osteoporosis and related disorders
Chapter 24. Genetics and genomics of chronic kidney disease
Chapter 25. Genetics and genomics in clinical hematology, I: Hemostasis and thrombosis
Chapter 26. Genetics and genomics in clinical hematology, II: Inherited disorders of hemoglobin
Chapter 27. Genetic and genomics in clinical hematology, III: Acute leukemias
Chapter 28. Genetics and genomics of chronic inflammatory disorders, I: Inflammatory bowel disease
Chapter 29. Genetics and genomics of chronic inflammatory disorders, II: Rheumatoid arthritis and related arthropathies
Chapter 30. Genetics and genomics of chronic inflammatory disorders, III: Bronchial asthma
Chapter 31. Genetics and genomics of neuro-psychiatric diseases, I: Seizure disorders
Chapter 32. Genetics and genomics of neuro-psychiatric diseases, II: Multiple sclerosis
Chapter 33. Genetics and genomics of neuro-psychiatric diseases, III: The common dementias
Chapter 34. Genetics and genomics of neuro-psychiatric diseases, IV: Schizophrenia and bipolar disorder
Chapter 35. Genetics and genomics of neuro-psychiatric diseases, V: Learning and behavioral disorders
Chapter 36. Clinical cancer genomics
Chapter 37. Genomics and infectious diseases: susceptibility, resistance, response, and antimicrobial therapy
Chapter 38. Genomic perspectives of clinical immunology
Chapter 39. Genomic applications in clinical pediatrics
Chapter 40. Genetics and genomics in clinical ophthalmology, I: The spectrum of genetic eye disease
Chapter 41. Genetics and genomics in clinical ophthalmology, II: Glaucoma
Chapter 42. Genetics and genomics in clinical ophthalmology, III: Age-related macular degeneration
Chapter 43. Genomic applications in audiological medicine
Chapter 44. Genetics and genomics of skin diseases I: Atopic dermatitis and other skin complex diseases
Chapter 45. Genetics and genomics of skin diseases, II: Genomics of pigmentation and skin cancer
Chapter 46. The genetic and genomic practice of reproductive medicine
Chapter 47. Stem cell genomics: Developmental competence
Chapter 48. Genomic applications in critical care medicine
Chapter 49. Molecularly targeted therapy for Mendelian disorders
Chapter 50. Glossary for genetic and genomic medicine