Mitochondrial Dysfunction in Neurodegenerative Disorders, 2nd Edition

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.

Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins.

Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Table of Contents

Part I: Mitochondria and Neurodegenerative Disease
Chapter 1: An Introduction to Mitochondria, Their Structure and Functions

Part II: Mitochondrial Dysfunction: Causes and Effects?
Chapter 2: Neurodegeneration in Mitochondrial Disorders
Chapter 3: The Ageing Brain, Mitochondria and Neurodegeneration
Chapter 4: Mitochondrial Genes and Neurodegenerative Disease
Chapter 5: Mitochondrial Signaling and Neurodegeneration

Part III: Functional Consequences of Mitochondrial Dysfunction
Chapter 6: Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease
Chapter 7: Mitochondrial Dynamics and Neurodegeneration
Chapter 8: Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation
Chapter 9: Mitochondria, the Synapse, and Neurodegeneration
Chapter 10: Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration
Chapter 11: Mitochondrial Degradation, Autophagy and Neurodegenerative Disease
Chapter 12: The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria

Part IV: Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease
Chapter 13: Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?
Chapter 14: Mitochondrial Function and Dynamics Imaged In Vivo

Part V: The Future
Chapter 15: Development of Treatments and Therapies to Target Mitochondrial Dysfunction
Chapter 16: Summary and Conclusions