Molecular and Biochemical Toxicology, 5th Edition

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.

• Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies
• Uses a didactic approach with basic biological or theoretical background for the methodology presented
• Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology
• Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts
• “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail…. It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Table of Contents

Section 1: Introduction
Chapter 1 Molecular And Biochemical Toxicology

Section 2: Techniques in Biochemical and Molecular Toxicology
Chapter 2 Molecular Techniques For The Study Of Gene Function
Chapter 3 Transcriptomics
Chapter 4 Proteomics
Chapter 5 Metabolomics
Chapter 6 Cellular Techniques
Chapter 7 Basic Concepts Of Molecular Epidemiological Research Methods

Section 3: Mechanisms in Molecular and Biochemical Toxicology
Chapter 8 Phase I And Phase Ii Metabolism And Metabolic Interactions
Chapter 9 Structure, Mechanism, And Regulation Of Cytochromes P450
Chapter 10 Polymorphisms In Phase I And Phase Ii Genes And Outcomes
Chapter 11 Cellular Transport And Elimination
Chapter 12 Nuclear Receptors
Chapter 13 Mechanisms Of Cell Death
Chapter 14 Mitochondrial Dysfunction
Chapter 15 Reactive Metabolites, Reactive Oxygen Species (Ros), And Toxicity
Chapter 16 Dna Damage And Mutagenesis
Chapter 17 Dna Repair
Chapter 18 Carcinogenesis

Section 4: Molecular and Biochemical Aspects of Organ Toxicology
Chapter 19 Molecular Mechanisms Of Respiratory Toxicity
Chapter 20 Molecular Mechanisms Of Hepatotoxicity
Chapter 21 Molecular Mechanisms Of Renal Toxicology
Chapter 22 Molecular Mechanisms Of Neurotoxicity
Chapter 23 Molecular Mechanisms Of Immunotoxicity
Chapter 24 Molecular Mechanisms Of Reproductive Toxicity
Chapter 25 Molecular Mechanisms Of Developmental Toxicity

Section 5: Emerging Areas in Molecular and Biochemical Toxicology
Chapter 26 Computational And Molecular Approaches To Risk Assessment
Chapter 27 Nanotoxicology
Chapter 28 Developmental Origins Of Health And Disease
Chapter 29 Exposome