Neuromuscular Disorders, 2nd Edition

A full-color text on neuromuscular disorders that bridges the gap between translational science and practical application

Neuromuscular Disorders is comprehensive in scope, yet concise enough to serve as a valuable point-of-care guide for your daily practice. Grounded by numerous reference sources and enhanced by the experience of two seasoned clinicians, this text provides a pragmatic approach in the evaluation and management of neuromuscular diseases. Here, in a single-source, you will get an insightful look at both nerve and muscle conditions, ranging from motor neuron disease to neuropathies, neuromuscular junction disorders, and myopathies.

Every chapter in this edition has been rewritten, in many cases extensively, with the addition of contemporary citations. The content reflects the latest advances in the imaging, genetic, and immunological tools now at our disposal to understand and diagnose many neuromuscular disorders.

Highlights include:

• Three new chapters covering the principles of immunomodulating treatment and the rehabilitation of neuromuscular diseases and other disorders that may be mistaken as neuromuscular mimics
• A unique blend of evidence-based medicine with the personal experiences of veteran clinicians
• Convenient coverage of nerve, and muscle and neuromuscular transmission disorders―both primary and secondary neuromuscular diseases
• Specific disease sections encompass the range of conditions likely to be encountered in clinical practice, including amyotrophic lateral sclerosis, myasthenia gravis, radiculopathies and plexopathies, mononeuropathies, various polyneuropathies, toxic myopathies, and dozens more
• The very latest diagnosis and treatment recommendations and protocols based on the most recent clinical literature and research
• Hundreds of figures including original art, EMGs, histopathology images, and clinical photos

Table of Contents

SECTION I: EVALUATION AND MANAGEMENT OF PATIENTS WITH NEUROMUSCULAR DISEASE
Chapter 1. Approach to Patients with Neuromuscular Disease
Chapter 2. Testing in Neuromuscular Disease
Chapter 3. Muscle and Nerve Histopathology
Chapter 4. Principles of Immunomodulating Treatment
Chapter 5. The Rehabilitation of Neuromuscular Diseases

SECTION II: SPECIFIC DISORDERS
Chapter 6. Amyotrophic Lateral Sclerosis
Chapter 7. Hereditary Spastic Paraparesis
Chapter 8. Spinal Muscular Atrophies
Chapter 9. Other Motor Neuron Disorders
Chapter 10. Disorders of Motor Nerve Hyperactivity
Chapter 11. Charcot–Marie–Tooth Disease and Related Disorders
Chapter 12. Other Hereditary Neuropathies
Chapter 13. Guillain–Barré Syndrome and Related Disorders
Chapter 14. Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Related Neuropathies
Chapter 15. Vasculitic Neuropathies
Chapter 16. Neuropathies Associated with Systemic Disease
Chapter 17. Neuropathies Associated with Infections
Chapter 18. Neuropathies Related to Nutritional Deficiencies
Chapter 19. Neuropathies Associated with Malignancy
Chapter 20. Toxic Neuropathies
Chapter 21. Neuropathies Associated with Endocrinopathies
Chapter 22. Idiopathic Polyneuropathy
Chapter 23. Focal Neuropathies of the Upper Extremities and Trunk: Radiculopathies, Brachial Plexopathies, and Mononeuropathies
Chapter 24. Focal Neuropathies of the Lower Extremities: Radiculopathies, Plexopathies, and Mononeuropathies
Chapter 25. Autoimmune Myasthenia Gravis
Chapter 26. Other Disorders of Neuromuscular Transmission
Chapter 27. Muscular Dystrophies
Chapter 28. Congenital Myopathies
Chapter 29. Metabolic Myopathies
Chapter 30. Mitochondrial Disorders
Chapter 31. Myotonic Dystrophies
Chapter 32. Nondystrophic Myotonias and Periodic Paralysis
Chapter 33. Inflammatory Myopathies
Chapter 34. Myopathies Associated with Systemic Disease
Chapter 35. Toxic Myopathies
Chapter 36. Neuromuscular Mimics