Organic Chemistry, Global Edition, 8th edition

y Paul Mee, A. J. Karrer (Author)

For courses in Organic Chemistry (2-Semester)

A framework for organic chemistry built around the similarities in reaction types

Paula Bruice’s presentation in Organic Chemistry, Eighth Edition provides mixed-science majors with the conceptual foundations, chemical logic, and problem-solving skills they need to reason their way to solutions for diverse problems in synthetic organic chemistry, biochemistry, and medicine. The Eighth Edition builds a strong framework for thinking about organic chemistry by unifying principles of reactivity that students will apply throughout the course, discouraging memorization. With more applications than any other textbook, Dr. Bruice consistently relates structure and reactivity to what occurs in our own cells and reinforces the fundamental reason for all chemical reactions–electrophiles react with nucleophiles. New streamlined coverage of substitution and elimination, updated problem-solving strategies, synthesis skill-building applications and tutorials guide students throughout fundamental and complex content in both the first and second semesters of the course

The textbook bridges the gap between organic chemistry and biochemistry

Because bioorganic chemistry is the bridge between organic chemistry and biochemistry, the text emphasizes that the organic reactions that chemists carry out in the laboratory are similar to those performed by nature inside a cell. These connections are especially important to biological science majors.

In Chapters 1-20, the bioorganic material is presented as “interest boxes” and within the last sections of the chapters so that this material is available to the student without requiring the instructor to introduce bioorganic topics into the course.
Chapters 21—26 focus on the organic chemistry of living systems. These chapters have the unique distinction of containing more chemistry than is typically found in the corresponding parts of a biochemistry text.
Chapter 21 Amino Acids, Peptides, And Proteins
Chapter 22 Catalysis In Organic Reactions And In Enzymatic
Chapter 23 The Organic Mechanisms Of The Coenzymes, Compounds Derived From Vitamins
Chapter 24 The Organic Chemistry Of The Metabolic Pathways
Chapter 25 The Organic Chemistry Of Lipids
Chapter 26 The Chemistry Of The Nucleic Acids

Table of Contents

PART ONE: An Introduction to the Study of Organic Chemistry
1 Remembering General Chemistry: Electronic Structure and Bonding
2 Acids and Bases: Central to Understanding Organic Chemistry
3 An Introduction to Organic Compounds: Nomenclature, Physical Properties, and Structure

PART TWO: Electrophilic Addition Reactions, Stereochemistry, and Electron Delocalization
4 Isomers: The Arrangement of Atoms in Space
5 Alkenes: Structure, Nomenclature, and an Introduction to Reactivity • Thermodynamics and Kinetics
6 The Reactions of Alkenes • The Stereochemistry of Addition Reactions
7 The Reactions of Alkynes • An Introduction to Multistep Synthesis
8 Delocalized Electrons: Their Effect on Stability, pK[Sub(a)] , and the Products of a Reaction • Aromaticity and Electronic Effects: An Introduction to the Reactions of Benzene

PART THREE: Substitution and Elimination Reactions
9 Substitution and Elimination Reactions of Alkyl Halides
10 Reactions of Alcohols, Ethers, Epoxides, Amines, and Sulfur-Containing Compounds
11 Organometallic Compounds
12 Radicals

PART FOUR: Identification of Organic Compounds
13 Mass Spectrometry; Infrared Spectroscopy; UV/Vis Spectroscopy
14 NMR Spectroscopy

PART FIVE: Carbonyl Compounds
15 Reactions of Carboxylic Acids and Carboxylic Acid Derivatives
16 Reactions of Aldehydes and Ketones • More Reactions of Carboxylic Acid Derivatives
17 Reactions at the α-Carbon

PART SIX: Aromatic Compounds
18 Reactions of Benzene and Substituted Benzenes
19 More About Amines • Reactions of Heterocyclic Compounds

PART SEVEN: Bioorganic Compounds
20 The Organic Chemistry of Carbohydrates
21 Amino Acids, Peptides, and Proteins
22 Catalysis in Organic Reactions and in Enzymatic Reactions
23 The Organic Chemistry of the Coenzymes, Compounds Derived from Vitamins
24 The Organic Chemistry of the Metabolic Pathways
25 The Organic Chemistry of Lipids
26 The Chemistry of the Nucleic Acids

PART EIGHT: Special Topics in Organic Chemistry
27 Synthetic Polymers
28 Pericyclic Reactions

Appendices
I: PK[Sub(A)] VALUES
II: KINETICS
III: SUMMARY OF METHODS USED TO SYNTHESIZE A PARTICULAR FUNCTIONAL GROUP
IV: SUMMARY OF METHODS EMPLOYED TO FORM CARBON-CARBON BONDS
V: SPECTROSCOPY TABLES
VI: PHYSICAL PROPERTIES OF ORGANIC COMPOUNDS