Patterning and Cell Type Specification in the Developing CNS and PNS

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems.

• Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
• Features leading experts in various subfields as Section Editors and article Authors
• All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
• Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

Table of Contents

Section I: Induction and Patterning of the CNS and PNS
Chapter 1: Telencephalon Patterning
Chapter 2: Morphogens, Patterning Centers, and their Mechanisms of Action
Chapter 3: Midbrain Patterning: Isthmus Organizer, Tectum Regionalization, and Polarity Formation
Chapter 4: Area Patterning of the Mammalian Cortex
Chapter 5: The Formation and Maturation of Neuromuscular Junctions
Chapter 6: Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells
Chapter 7: Spinal Cord Patterning
Chapter 8: Patterning of the Diencephalon
Chapter 9: Neural Induction Embryonic Stem Cells
Chapter 10: Plan of the Developing Vertebrate Nervous System: Relating Embryology to the Adult Nervous System (Prosomere Model, Overview of Brain Organization)
Chapter 11: Cerebellar Patterning
Chapter 12: Hox Genes and Neural Patterning in Drosophila
Chapter 13: Induction and Patterning of Neural Crest and Ectodermal Placodes and their Derivatives

Section II: Generation of Neuronal Diversity
Chapter 14: Cell Biology of Neuronal Progenitor Cells
Chapter 15: Cell Cycle Regulation in Brain Construction
Chapter 16: Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System
Chapter 17: Notch and Neural Development
Chapter 18: bHLH Factors in Neurogenesis and Neuronal Subtype Specification
Chapter 19: Environmental Cues and Signaling Pathways that Regulate Neural Precursor Development
Chapter 20: Specification of Neural Crest- and Placode-Derived Neurons
Chapter 21: The Specification and Generation of Neurons in the Ventral Spinal Cord
Chapter 22: Neurogenesis in the Cerebellum
Chapter 23: The Generation of Midbrain Dopaminergic Neurons
Chapter 24: Neurogenesis in the Basal Ganglia
Chapter 25: Specification of Cortical Projection Neurons: Transcriptional Mechanisms
Chapter 26: The Generation of Cortical Interneurons
Chapter 27: Specification of Retinal Cell Types
Chapter 28: Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity
Chapter 29: Neurogenesis in the Damaged Mammalian Brain
Chapter 30: Neurogenesis in the Nematode Caenorhabditis elegans*
Chapter 31: Development of the Drosophila Embryonic Ventral Nerve Cord: From Neuroectoderm to Unique Neurons and Glia
Chapter 32: Neurogenesis in Zebrafish

Section III: Development of Glia, Blood Vessels, Choroid Plexus, Immune Cells in the Nervous System
Chapter 33: `Glial´ Biology: Has it Come to the Beginning of the End?
Chapter 34: Neural Stem Cells Among Glia
Chapter 35: Structure and Function of Myelinated Axons
Chapter 36: Mechanisms of Astrocyte Development
Chapter 37: Specification of Macroglia by Transcription Factors: Oligodendrocytes
Chapter 38: Specification of Macroglia by Transcription Factors: Schwann Cells
Chapter 39: Signaling Pathways that Regulate Glial Development and Early Migration – Oligodendrocytes
Chapter 40: Signaling Pathways that Regulate Glial Development and Early Migration – Schwann Cells
Chapter 41: Microglia
Chapter 42: Ependyma, Choroid
Chapter 43: Meninges and Vasculature
Chapter 44: Neuron-Glial Interactions: Schwann Cells
Chapter 45: Neuron-Glial Interactions: Neurotransmitter Signaling to Cells of the Oligodendrocyte Lineage
Chapter 46: Invertebrate Glia
Chapter 47: Nonmammalian Model Systems: Zebrafish
Chapter 48: New Approaches in Glial Biology: Imaging Neuroglial Pathology In Vivo