Schaechter’s Mechanisms of Microbial Disease, 5th Edition

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Schaechter’s Mechanisms of Microbial Disease provides students with a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text is universally praised for “telling the story of a pathogen” in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. The table of contents is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. Case studies with problem-solving questions give students insight into clinical applications of microbiology, which is ideal for problem-based learning.

Table of Contents

PART I: Principles
Chapter 1: Establishment of Infectious Diseases
Chapter 2: The Normal Microbiota
Chapter 3: Biology of Infectious Agents
Chapter 4: Genetic Approaches to Studying Bacterial Pathogenesis
Chapter 5: Biological Basis for Antibacterial Action
Chapter 6: Innate Immunity
Chapter 7: Adaptive Immunity
Chapter 8: The Parasite’s Way of Life
Chapter 9: Damage by Microbial Toxins

PART II: Infectious Agents
SECTION 1: BACTERIA
Chapter 10: Introduction to the Pathogenic Bacteria
Chapter 11: Staphylococci: Abscesses and Toxin-Mediated Diseases
Chapter 12: Streptococci and Enterococci: “Step Throat” and Beyond
Chapter 13: Pneumococcus and Bacterial Pneumonia
Chapter 14: Neisseriae: Gonococcus and Meningococcus
Chapter 15: Bacteroides, Intra-Abdominal Infection, and Abscesses
Chapter 16: Enteric Bacteria: Secretory Diarrhea
Chapter 17: Invasive and Tissue-Damaging Enteric Bacterial Pathogens: Bloody Diarrhea and Dysentery
Chapter 18: Pseudomonas aeruginosa: A Ubiquitous Opportunist
Chapter 19: Bordetella and Whooping Cough
Chapter 20: Clostridia: Diarrheal Disease, Tissue Infection, Botulism, and Tetanus
Chapter 21: Legionella: Parasite of Amoebae and Macrophages
Chapter 22: Helicobacter pylori: Pathogenesis of a Persistent Bacterial Infection
Chapter 23: Mycobacteria: Tuberculosis and Leprosy
Chapter 24: Syphilis: A Disease with a History
Chapter 25: Borrelia burgdorferi and Lyme Disease
Chapter 26: Cat Scratch Disease, Bacillary Angiomatosis, and Other Bartonelloses
Chapter 27: Chlamydiae: Genital, Ocular, and Respiratory Pathogens
Chapter 28: Rocky Mountain Spotted Fever and Other Rickettsioses
Chapter 29: Mycoplasma: Curiosity and Pathogen
Chapter 30: Strategies to Combat Bacterial Infections
SECTION 2: VIRUSES
Chapter 31: Biology of Viruses
Chapter 32: Picornaviruses and Coronaviruses
Chapter 33: Arthropodborne Viruses
Chapter 34: Paramyxoviruses: Measles Virus and Respiratory Syncytial Virus
Chapter 35: Rabies
Chapter 36: Influenza and Its Viruses
Chapter 37: Rotaviruses, Noroviruses, and Other Viral Agents of Gastroenteritis
Chapter 38: The Human Retroviruses: AIDS and Other Diseases
Chapter 39: Adenoviruses
Chapter 40: Human Papillomaviruses and Warts
Chapter 41: Alphaherpesviruses: Herpes Simplex Viruses and Varicella-Zoster Virus
Chapter 42: Beta- and Gammaherpesviruses: Cytomegalovirus and Epstein-Barr Virus
Chapter 43: Viral Hepatitis
Chapter 44: Antiviral Treatment Strategies
Chapter 45: Vaccines and Antisera for the Prevention and Treatment of Infectious Diseases
SECTION 3: FUNGI
Chapter 46: Introduction to the Fungi and Mycoses
Chapter 47: Endemic Mycoses
Chapter 48: Opportunistic Fungal Infections
Chapter 49: Subcutaneous, Cutaneous, and Superficial Mycoses
Chapter 50: Antifungal Agents
SECTION 4: PARASITES
Chapter 51: Introduction to Parasitology
Chapter 52: Blood and Tissue Protozoa
Chapter 53: Intestinal and Vaginal Protozoa
Chapter 54: Intestinal Helminths
Chapter 55: Tissue and Blood Helminths
SECTION 5: MISCELLANEOUS PATHOGENS
Chapter 56: Prion Diseases
Chapter 57: Biological Agents of Warfare and Terrorism

PART III: Pathophysiology of Infectious Diseases
Chapter 58: Diagnostic Principles
Chapter 59: Principles of Epidemiology
Chapter 60: Digestive System Infections
Chapter 61: Infections of the Central Nervous System
Chapter 62: Respiratory System Infections
Chapter 63: Urinary Tract Infections
Chapter 64: Infections of the Skin and Soft Tissue
Chapter 65: Infections of the Bones, Joints, and Muscles
Chapter 66: Sepsis
Chapter 67: Intravascular Infection
Chapter 68: Head and Neck Infections
Chapter 69: Sexually Transmitted Diseases
Chapter 70: Infections of the Immunocompromised Patient
Chapter 71: Acquired Immunodeficiency Syndrome
Chapter 72: Congenital and Perinatal Infections
Chapter 73: Zoonoses
Chapter 74: Fever: A Clinical Sign of Infection
Chapter 75: Health Care–Associated Infections
Chapter 76: Foodborne Diseases
Appendix A: Answers to Case Questions
Appendix B: Quick Reference Summary Tables